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Longevity
intermediate
Strong Evidence

Biomarker Monitoring

Quarterly or semi-annual comprehensive blood work to detect dysfunction early and optimize interventions. Track metabolic, inflammatory, hormonal, and nutrient markers.

Time
1-2 hours every 3-6 months
Cost
$50+
Equipment
None required
Min. Trial
Ongoing

Dosage & Timing

Duration
1-2 hours per panel
Frequency
Every 3-6 months
Best Time
morning

Evidence Strength

4/5 — Strong
EvidenceStrong

Strong rationale for early detection and intervention. Specific biomarkers like ApoB, fasting insulin, and hs-CRP have robust predictive value for cardiometabolic disease.

Overview

Regular blood work and health metrics tracking to catch dysfunction early and measure protocol effectiveness. Key panels include metabolic (glucose, insulin, lipids), inflammatory (hs-CRP, homocysteine), hormonal, and nutrient status (D, B12, iron, omega-3 index).

Wellness education and routine support only. Review the evidence, caveats, and interactions before trying this protocol, and ask a clinician when medical conditions, pregnancy, medications, or symptoms are involved.

How To Do It

  1. 1

    Get a comprehensive panel

    Key markers: Fasting glucose, fasting insulin (calculate HOMA-IR), HbA1c, lipid panel with ApoB, hs-CRP, homocysteine, 25(OH)D, omega-3 index, CBC, metabolic panel.

  2. 2

    Request the right tests

    Standard panels miss critical markers. Specifically ask for: ApoB, fasting insulin, Lp(a) (once), hs-CRP.

  3. 3

    Track trends over time

    Single readings matter less than trends. Use a spreadsheet or app to track over time.

  4. 4

    Adjust protocols based on results

    Use data to titrate supplement doses, adjust diet, and verify your protocols are working.

The Evidence

Each claim is linked to its source study. Confidence reflects the study design — systematic reviews and RCTs rank highest.

Broad health checks have mixed outcome evidence, so biomarker testing should be targeted and actionable.

Source Context

Primary references behind the protocol summary.

1 primary source
Cochrane ReviewGeneral health checks in adults for reducing morbidity and mortality from disease (https://doi.org/10.1002/14651858.CD009009.pub3)

Who Popularized This

Creator references are context only. LiveWell weighs evidence, safety notes, and routine fit separately from who discussed a protocol.

Peter Attia
Rhonda Patrick

Interactions & Warnings

Review 0 contraindications and 1 interaction note before adding this protocol to a routine.

Interactions

  • Use results to adjust supplement and nutrition protocols

What To Track

These are review prompts for your own routine notes, not expected improvements or medical outcome targets.

Optimized biomarker values
Early detection of metabolic dysfunction
Data-driven protocol adjustments

Routine actions change your saved plan after sign-in. The protocol guidance above remains wellness education, not a personalized recommendation or expected outcome.

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