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Exercise
intermediate
Very Strong Evidence

Resistance Training (3x/week)

Progressive overload strength training 3x/week. The single most protective exercise against age-related decline in muscle, bone, and metabolic health.

Time
3-4 hours/week
Cost
$50+
Equipment
Barbell and plates OR dumbbells +2 more
Min. Trial
8-12 weeks

Dosage & Timing

Duration
45-60 min/session
Frequency
3x/week
Best Time
anytime

Evidence Strength

5/5 — Very Strong

Overwhelming evidence. Resistance training is arguably the most important exercise modality for longevity and healthspan.

Overview

Three sessions per week of progressive overload resistance training using compound movements. This is the most important exercise modality for maintaining muscle mass, bone density, metabolic rate, and functional independence as you age.

How To Do It

1

Learn the big lifts

Squat, deadlift, bench press, overhead press, row. Start with bodyweight or light loads to learn form.

2

Follow a program

Use a structured program (Starting Strength, GZCLP, or 5/3/1 for beginners). Don't freestyle.

3

Progressive overload

Add weight, reps, or sets over time. Track every workout.

4

Prioritize compound movements

80% of your work should be multi-joint movements. Isolation work is supplementary.

Progression Path

Beginner: 3x full body. Intermediate: upper/lower split. Advanced: push/pull/legs or specialized programming.

The Evidence

Each claim is linked to its source study. Confidence reflects the study design — systematic reviews and RCTs rank highest.

Systematic Review and Meta-analysis
High Confidence

Muscle-strengthening activities and cancer incidence and mortality

Muscle-strengthening activity was associated with lower all-cause mortality risk.

Primary Literature

Systematic Review and Meta-analysis:Muscle-strengthening activities and cancer incidence and mortality (https://pubmed.ncbi.nlm.nih.gov/34051796/)

Who Popularized This

Andrew Galpin
Brad Schoenfeld
Peter Attia
Layne Norton

Interactions & Warnings

Contraindications

  • Acute injuries (modify around them)
  • Uncontrolled hypertension

Interactions

  • Pair with adequate protein intake (1.6-2.2g/kg)
  • Allow 48h between training same muscle group

Measurable Outcomes

Increased strength (tracked lifts)
Improved body composition
Better bone density (DEXA)
Enhanced metabolic rate

Equipment Needed

  • Barbell and plates OR dumbbells
  • Squat rack (ideal)
  • Bench
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