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Supplements
beginner
Very Strong Evidence

Creatine Monohydrate

3-5g daily of the most researched supplement in sports science. Benefits extend beyond muscle to cognition, bone health, and potentially neuroprotection.

Time
1 min/day
Cost
$0-20
Equipment
None required
Min. Trial
4-8 weeks

Dosage & Timing

Duration
Ongoing
Frequency
Daily
Best Time
anytime

Evidence Strength

5/5 — Very Strong
EvidenceVery Strong

The most studied supplement in exercise science. Hundreds of studies. Consistently shown to improve strength, power output, and lean mass. Cognitive benefits emerging.

Overview

Take 3-5g of creatine monohydrate daily. It is the most studied and effective legal supplement for strength, power, and lean mass. Emerging evidence also supports cognitive benefits, especially under stress or sleep deprivation.

Wellness education and routine support only. Review the evidence, caveats, and interactions before trying this protocol, and ask a clinician when medical conditions, pregnancy, medications, or symptoms are involved.

How To Do It

  1. 1

    Buy creatine monohydrate

    Plain creatine monohydrate is the best-studied form. No need for fancy versions (HCl, buffered, etc.).

  2. 2

    Take 3-5g daily

    Mix with water or your shake. Timing doesn't matter much — consistency does.

  3. 3

    No loading necessary

    Loading phases (20g/day for a week) work faster but aren't necessary. 3-5g/day reaches saturation in 3-4 weeks.

The Evidence

Each claim is linked to its source study. Confidence reflects the study design — systematic reviews and RCTs rank highest.

Creatine monohydrate is effective for strength, power, and lean mass outcomes.

Source Context

Primary references behind the protocol summary.

1 primary source
Position Stand and ReviewISSN position stand: safety and efficacy of creatine supplementation (https://pubmed.ncbi.nlm.nih.gov/28615996/)

Who Popularized This

Creator references are context only. LiveWell weighs evidence, safety notes, and routine fit separately from who discussed a protocol.

Layne Norton
Eric Trexler
Peter Attia

Interactions & Warnings

Review 1 contraindication and 2 interaction notes before adding this protocol to a routine.

Contraindications

  • Severe kidney disease (consult nephrologist)

Interactions

  • Take with carbohydrates for improved absorption
  • May cause 2-4 lbs water weight initially

What To Track

These are review prompts for your own routine notes, not expected improvements or medical outcome targets.

Increased strength and power output
Slight increase in lean mass
Improved high-intensity performance

Routine actions change your saved plan after sign-in. The protocol guidance above remains wellness education, not a personalized recommendation or expected outcome.

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